|
KMID : 1137020070180020101
|
|
Journal of Gynecologic Oncology
2007 Volume.18 No. 2 p.101 ~ p.107
|
|
|
The clinicopathologic significance of glandular cell abnormality on preoperative abnormal PAP smears in endometrial carcinoma
|
|
Hong Won-Ki
Lee In-Ho
Lee Ki-Heon
Park Sei-Jin
Kim Tae-Jin
Lim Kyung-Taek
Shim Jae-Uk
Hong Jae-Sik
Lim Jae-Yun
Kim Hee-Suk
|
|
|
Abstract
|
|
|
Objective: The aim of this study was to evaluate the correlation between the results of preoperative PAP smears and known poor prognostic factors in patients with endometrial carcinoma.
Methods: Between Jan. 2000 and Dec. 2003, preoperative evaluation of PAP smears were done in 111 patients with endometrial carcinoma who underwent surgical staging. Pathologic parameters of permanent specimens were evaluated and correlated with the results of PAP smears. χ2-test was used for statistical analysis and p-values ＜0.05 was considered as statistically significant.
Results: The mean age of patients was 49 years with range between 24 and 75 years old. The results of preoperative PAP smears were normal in 70 patients (57.7%), atypical glandular cells of undetermined significance (AGUS) in 22 patients (22.5%), adenocarcnoma in 19 patients (19.8%) on preoperative PAP smears. Statistically significant associations were found between preoperative PAP smears and poor histologic grade (p=0.000), depth of myometrial invasion (p=0.000), lymph-vascular space invasion (p=0.003), cervical involvement (p=0.004), adnexal involvement (p=0.024), positive peritoneal cytology (p=0.042). However, old age, poor histologic type, higher surgical staging, pelvic nodes metastasis and para-aortic lymph node metastases were not statistically significant.
Conclusion: This study revealed glandular cell abnormalities on preoperative PAP smears in patients with endometrial carcinoma were significantly associated with poor histologic grade, deep myometrial invasion, lympho-vascular invasion, cervical involvement, adnexal involvement, positive peritoneal cytology. Therefore, the results of preoperative PAP smears could be considered as an important part of the preoperative evaluation in patients with endometrial carcinoma.
|
|
|
KEYWORD
|
|
|
PAP smear, Endometrial carcinoma, Glandular cell abnormality, Prognostic factors
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|
|